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Rhabdomyolysis is often associated with novel physical exercise and exertional heat illness in warm temperatures. It is possible that accentuated hyperthermia might partially be responsible for these observations, but direct evidence is lacking. Previous research has not manipulated skeletal muscle temperature and evaluated its impact on muscle damage induced by a standardized eccentric exercise (ECCEX) challenge. It was hypothesized that local muscle heating (HEAT) applied just before ECCEX will cause greater skeletal muscle functional loss and damage compared to ECCEX performed without muscle heating (CON).

Does hyperthermia increase skeletal muscle damage from eccentric exercise?