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Results In procyclic cells KIN5 is localised in the flagellum (probably the axoneme), with a strong fluorescent signal at the distal tip. Depletion of KIN5 results in cells with a mispositioned and partially detached flagellum. The flagellum of the cells is still beating, but the cells are unable to swim. Nevertheless they divide normally indicating that they have adapted to the partially detached flagellum, probably by modifications of the intracellular organisation. Preliminary data indicate that the filament of the Flagellum Attachment Zone is smaller in length in cells depleted of KIN5.

A novel kinesin involved in flagellum attachment and positioning in Trypanosoma brucei