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Results Our expression studies indicate that a regulatory relationship might exist between FOXA2 and Pkd1l1. Furthermore, Shh and FoxA2;ShhcreER embryos display abnormal Pkd1l1 expression. Indeed, previous studies identified FOXA2 binding regions upstream of Pkd1l1, in both human and mouse. Our work has revealed the two regions to be non-homologous, but conserved in the human-mouse lineage, in some cases to the binding site level. Although bioinformatic analysis predicts lower binding affinities for the conserved mouse-identified region in human and vice versa, luciferase assays indicate that the conserved regions are capable of driving gene expression.

FOXA2 controls Pkd1l1 expression in the mouse node during left-right determination