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Results These analyses revealed a list of 272 genes that are found exclusively in organisms with sensory cilia but not motile cilia. Importantly, nearly 10% of the genes on this list have previously been implicated in sensory cilia-specific roles, thus providing numerous internal positive controls that demonstrate this list is enriched with sensory-specific ciliary genes. A subset of uncharacterized candidate genes are currently being studied in C. elegans, which retains cilia exclusively on a set of neurons termed ciliated sensory neurons (CSNs). We are currently generating a number of promoterand gene-to-green fluorescent protein (GFP) fusion constructs in order to determine the expression and localization patterns of the proteins encoded by these genes. Two of these candidate genes, which are found in worms (C. elegans) and algae (C. reinhardtii) but not in moss (P. patens) have been termed wam-1 and wam-2, respectively. Expression of wam-1 appears to be localized exclusively in the support cells of ciliated dopaminergic neurons, while expression of wam-2 has yet to be fully characterized. Conclusion Our analyses have successfully revealed novel genes involved in ciliary sensory-specific processes in animals.

Comparative genomics reveals novel genes associated with sensory cilia