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Background The intraflagellar transport (IFT) complex is an ancient protein complex that facilitates active trafficking of proteins and molecules across the eukaryotic cilium. Based on similar domain compositions Avidor-Reiss et al. (2004) and Jekely et al. (2006) postulated that the IFT originates from an ancestral proto-coatomer complex that also gave rise to vesicle coating complexes (e.g. COPI, COPII, Clathrin) and the Nuclear Pore Complex. Using comparative genomics we provide direct phylogenetic evidence of the proto-coatomer origin of the IFT.

Origin and extension of the IFT complex in early eukaryotic evolution