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The transcription factor  Oct4  ( Pou5f1 ) is a critical regulator of pluripotency in embryonic and induced pluripotent stem cells. Therefore,  Oct4  expression might identify somatic stem cell populations with inherent multipotent potential or a propensity for facilitated reprogramming. However, analysis of  Oct4  expression is confounded by  Oct4  pseudogenes or non-pluripotency-related isoforms. Systematic analysis of a transgenic  Oct4-EGFP  reporter mouse identified testis and skin as two principle sources of  Oct4   +  cells in postnatal mice. While the prevalence of GFP +  cells in testis rapidly declined with age, the skin-resident GFP +  population expanded in a cyclical fashion. These cells were identified as epidermal stem cells dwelling in the stem cell niche of the hair follicle, which endogenously expressed all principle reprogramming factors at low levels. Interestingly, skin wounding or non-traumatic hair removal robustly expanded the GFP +  epidermal cell pool not only locally, but also in uninjured skin areas, demonstrating the existence of a systemic response. Thus, the epithelial stem cell niche of the hair follicle harbors an expandable pool of Oct4+ stem cells, which might be useful for therapeutic cell transfer or facilitated reprogramming.   Electronic supplementary material  The online version of this article (doi: 10.1186/2045-9769-3-9) contains supplementary material, which is available to authorized users.

Genetic reporter analysis reveals an expandable reservoir of OCT4+ cells in adult skin