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In patients with idiopathic normal pressure hydrocephalus (iNPH), one of the potential factors that may negatively influence the shunt responsiveness is the presence of comorbidity, especially the Alzheimeru0027s disease (AD) that results in progressive dementia. It is hence essential to conduct an accurate diagnosis on whether each patient with iNPH has comorbid AD. Recently, positron emission tomography (PET) using 11C-labeled radiotracer Pittsburgh Compound B (PIB) has been widely applied for the in vivo assessment of amyloid-β (Aβ) deposition in patients with AD. To elucidate the incidence and distribution of the cortical retention of Pittsburgh Compound B (PIB) in patients with iNPH and clarify the differences from those in patients with AD.

Distribution of amyloid burden is different between idiopathic normal pressure hydrocephalus and Alzheimer's disease