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iNPH is characterized by a wide range of neuropsychological deficits. The severity of impairment is associated with that of gait, balance and continence disturbances, and correlations between results on disparate neuropsychological tests are far stronger than among healthy; a dedifferentiation of functions.  Following surgery, performance at group level, is significantly improved and remains stable for at least the first year of treatment. Importantly, however, shunted iNPH patients still perform well below normal levels.  The magnitude of change varies substantially, some patients showing only modest advances or even further deterioration, whereas others show considerable improvements on the majority or all administered tests.  In this study we compared patients belonging to these two extremes, aiming to predict neuropsychological benefits of surgery.

Neuropsychological effects of shunting in iNPH – determining major and minor responses