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An improved, cost effective process for the synthesis of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide; a key intermediate for the preparation of Tolterodine and its related substances were described. The process features one pot synthesis employing inexpensive reagents.

sustainable chemical processes

Improved one-pot synthesis of N, N-diisopropyl-3-(2-Hydroxy-5-methylphenyl)-3-phenyl propanamide; a key intermediate for the preparation of racemic Tolterodine