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Background  The Onychophora are a probable sister group to Arthropoda, one of the most intensively studied animal phyla from a developmental perspective. Pioneering work on the fruit fly  Drosophila melanogaster  and subsequent investigation of other arthropods has revealed important roles for  Wnt  genes during many developmental processes in these animals.    Results  We screened the embryonic transcriptome of the onychophoran  Euperipatoides kanangrensis  and found that at least 11  Wnt  genes are expressed during embryogenesis. These genes represent 11 of the 13 known subfamilies of  Wnt  genes.    Conclusions  Many onychophoran  Wnt  genes are expressed in segment polarity gene-like patterns, suggesting a general role for these ligands during segment regionalization, as has been described in arthropods. During early stages of development,  Wnt2 ,  Wnt4 , and  Wnt5  are expressed in broad multiple segment-wide domains that are reminiscent of arthropod gap and  Hox  gene expression patterns, which suggests an early instructive role for  Wnt  genes during  E. kanangrensis  segmentation.

Analysis of the Wnt gene repertoire in an onychophoran provides new insights into the evolution of segmentation