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Background  The emergence of multidrug-resistant strains of  Mycobacterium tuberculosis  (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular interest.    Methods  This study is focused on propargyl acetate derivatives. Eight molecules were designed based on propargyl alcohols and different acid anhydrides.    Results  All the synthesized compounds and commercially available ones were evaluated for anti-tuberculosis activity.    Conclusions  Inhibitors against Mtb have been identified and characterized for further development into potential novel anti-tubercular drugs.

Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents