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Background  In the recent years, there is an increasing attention to the using of Fe 3 O 4  magnetite nanoparticles (MNPs) as drug delivery systems. Application of this nanoparticles could profit advantages of nanomedicine to enhance biological activity of pharmaceutical ingredients.    Methods  Fe 3 O 4  MNPs were synthesised by a chemical method and characterized by transmission electron microscopy and energy-dispersive spectroscopy techniques. In the next step, docetaxel-coated Fe 3 O 4  MNPs were prepared, using percipitation method. The surface chemistry of docetaxel-coated Fe 3 O 4  MNPs as well as their thermal decomposition characteristics were examined using fourier transform infrared spectroscopy and thermogravimetric analyzer equipment, respectively. The cytotoxicity assay was conducted on 4 T1 breast cancer carsinoma by MTT assay to evaluate the possible  in vitro  antiproliferative effects of docetaxel-coated Fe 3 O 4  MNPs.    Results  During precipitation process, docetaxel molecules were precipitated on the surface of Fe 3 O 4  MNPs by the ratio of 3:100 w/w which indicates that each milligram of coated Fe 3 O 4  MNPs averagely contained 30 μg pure docetaxel compound. Docetaxel showed aniproliferative effects against mentioned cell line. The higestest concentartion of docetaxel (80 μg/ml) caused about 80% cell death. However, the results demostarted that much lower amounts of docetaxel will be needed in combination of Fe 3 O 4  MNPs to produce the potent antiproliferative effect compared to docetaxel alone. Dose response cytotoxicity assay of docetaxel-coated Fe 3 O 4  MNPs against 4 T1 breast cancer cells showed that lower amount of docetaxel (0.6 μg/ml) can exhibit higher cytotoxic effect against this cancer cell line (90% cell death).

Fabrication of docetaxel surfaced Fe3O4 magnetite nanoparticles and their cytotoxicity on 4 T1 breast cancer cells