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Background Family history-based risk assessment (FHRA) is a validated genetic tool for identifying those at moderate and high risks of disease. The latter usually result from gene mutations conferring high risks of disease. Genomewide association studies (GWAS) have resulted in single nucleotide polymorphisms (SNP) statistically associated with lowto moderate-level risks of diseases or traits. With increased access and decreasing price-point for SNP profile-based risk assessment for common diseases, such as colon cancer, health-professionals and consumers are questioning how this type of genetic risk assessment compares to the standard of FHRA. To date, there has been limited study of concordance for these two methods of disease-risk assessment.

Comparison of family health history to personal genomic screening for risk assessment of colon cancer