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3020insC in the NOD2 gene increases the risk of: • breast cancer DCIS below age 50 about 5-fold – this mutation is detected in 8% of all breast cancer cases, • colorectal cancer approximately 2-fold above age 60 – this mutation is present in 15% of all colorectal cancer cases, • lung cancer about 2-fold – this mutation is present in 12% of all lung cancer cases, • ovarian cancer about 1.5-fold – this mutation is present in 11% of all ovarian cancer cases [1, 2].

DNA testing for variants conferring low or moderate increase in the risk of cancer