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The editors of this journal have approached a number of geneticists and genetic counsellors from different countries to obtain their comments on the paper by van Oostrom and Tibben which appeared in a recent issue of the journal (2004; 2 (1):19-23). In this paper, the authors proposed a simplified procedure for presymptomatic testing of BRCA1/2 mutations, which departs from the ”Huntington-model”. Although the editor’s survey was not designed to give a representative overview of international approaches towards presymptomatic testing for BRCA1 and 2 mutations, it does give the readers a flavour of the findings and concerns of some of our colleagues from the field and highlights some of the similarities and differences between current practices in different clinics. We do not fully reproduce all comments here, but rather quote and summarise selectively the most illustrative remarks and have asked van Oostrom and Tibben for a response.

Presymptomatic DNA Testing in BRCA1/2. Invited reactions from the field on the van Oostrom and Tibben paper