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Methods We performed an international multi-center study of 1,470 EOC cases with pathogenic germline mutations in BRCA1 (1,134) or BRCA2 (336) and 2,814 non-carriers. Our goal was to further characterize the survival of BRCA carriers with EOC compared to non-carriers and to determine whether BRCA1 and BRCA2 carriers show similar survival patterns. Cox proportional hazards regression, both unadjusted and adjusted for other prognostic variables, was used to measure differences in overall survival during the five years following diagnosis.

A multi-center study to evaluate the impact of germline BRCA1 and BRCA2 mutations on ovarian cancer survival