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Aims Thiamine is reabsorbed by the transporters THTR1 and THTR2 (encoded by SLC19A2 and SLC19A3 genes, respectively) in kidney proximal tubule. Decreased plasmatic thiamine concentrations resulting from increased renal clearance was demonstrated in type 2 and type 1 diabetes (T1D) patients. Increased thiamine urinary excretion is an independent risk factor for renal function decline in T1D patients. To evaluate the participation of THTR1 and THTR2 in the pathogenesis of diabetic nephropathy (DN), we studied the expression of SLC19A2 and SLC19A3 in urinary sediment (US) and peripheral blood mononuclear cells (PBMC) in T1D. We also evaluated plasmatic thiamine concentrations to get insights about its status in our population.

Increased thiamine transporter 1 RNA expression in the urinary sediment of type 1 diabetes patients with diabetic kidney disease