English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background Maturity-onset Diabetes of the Young (MODY; OMIM# 606391) is often related to a single gene mutation and characterized by dominant inheritance and non-insulindependent DM with a young age at diagnosis (Fajans et al., 2001). The most frequent subtype, MODY2, Results from SNPs in the glucokinase gene (Osback et al., 2009). Mapped to human chromosome 7p15.3-p15.1, the GCK gene consists of 10 exons and roughly 45 Kb. More than 600 SNPs were reported to this gene and among those, around 200 are related to the disease (Osback et al., 2009).

Could one splicing-site single nucleotide polymorphism cause the MODY2 disease?