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of results Mean duration of therapy in the patients with NVP regimen at the recruitment was 7.3 ± 1.9 years. Forty-three patients (35.9%) were antiretroviral-naive: mean HIVRNA level was 50,000 copies/ml (range 2,000–214,000) and mean CD4 cells count was 386 cell/mm3 (11–976). Seventy-seven patients (64.1%) switched to NVP for simplification or intolerance: mean viral load was 100,000 copies/ml (range 49–>500,000) and mean CD4 cells count was 450 cell/mm3 (30–1,600). Baseline characteristics included liver enzymes (ALT 31.6, AST 41.2 and GGT 23.4) and fasting lipid profile (total cholesterol 202.4, HDL-cholesterol 59.17, LDL-cholesterol 131.4 and triglycerides 210.7). Co-infection with hepatitis C viruses were present in 25 (20.8%) patients. The efficacy and tolerability were evaluated at three time points for analysis: baseline, at 2 years, and at 4 years after baseline. At the last measurement, all patients had undetectable viral loads (<50 copies/ml) and the mean CD4 cells count increased from baseline values by 340 cells/mm3. In naive patients viral loads decreased during the first 6 months (range 3–9 months).

Efficacy and tolerability of long-term nevirapine plus nucleoside reverse transcriptase inhibitors for HIV-1 infection