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Methods Ribavirin's serum concentration was measured in 20 HIV/ HCV co-infected patients who were eligible for HCV treatment 4 weeks after treatment commenced. A serum concentration of 2.2 microgram/ml is considered as therapeutic level. Dose of ribavirin was increased as 200 milligram daily (not more than 1,200 mg/day) in patients whose ribavirin serum concentration was less than 2.2 microgram/ml. Hemoglobin levels measured at first day of treatment and 3 months later.

Increased ribavirin dose in HIV/HCV co-infected patients leads to increased serum concentration of ribavirin