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Non-cirrhotic portal hypertension has recently emerged asa new entity in HIV-infected patients. Histological find-ings often reveal different hepatic portal perivascularabnormalities. In most cases it was related to previousdidanosine exposure. Although its recognition could bemore difficult, this drug-induced vascular damage in theliver might also appear in HIV/HCV co-infected patients.

Thrombopenia and/or splenomegaly in HIV/HCV co-infected patients with mild liver fibrosis alerts for the risk of portal hepatopathy