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Methods Retrospective analysis of all IFN-naive patients with chronic hepatitis C who received a full course of 48 weeks of pegIFN (alpha 2a or 2b, at standard doses) plus weightadjusted RBV (~13 mg/kg, 1,000–1,200 mg/day) therapy and had negative serum HCV-RNA at the end of treatment (EOT). Incidence and timing for HCV relapse were analyzed separately in HIV-pos and HIV-neg patients. Serum HCV-RNA was measured at EOT and every 3 months thereafter during the next year using a real-time PCR assay (Cobas Taqman, Roche), which has a lower limit of detection of 10 IU/mL.

HCV relapse after peg-interferon (IFN) plus ribavirin (RBV) therapy: is 12-week follow-up enough to determine sustained HCV clearance?