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Purpose of the study The resistance of antiretroviral drugs is mainly attributed by the generation of HIV variants in different secretions of the same individual; distinct viral variants have been detected in different cells and body fluids of the same individual. Genotypic and phenotypic characterization of viral variants in blood and urogenital secretions may provide strategies for designing modalities in prevention of sexual transmission of HIV and to explore the mechanism of sexual transmission of human immunodeficiency virus type 1(HIV-1).

Analysis of HIV variants in blood and semen in serodiscordants by heteroduplex mobility assay