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Purpose of the study Previous studies of our team have shown that Romanian teenagers horizontally infected with HIV in early childhood, have a high prevalence of HBV co-infection (78.3% being anti-HBc positive vs. 21.8% of age-matched HIVnegative controls). Our aim was to investigate the frequency of mutations and variables potentially associated with an increased risk of liver disease evolution in HIV/ HBV co-infected individuals receiving 2NRTI + 1PI boosted with ritonavir.

HIV lamivudine resistance mutations in HBV co-infected Romanian patients