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Methods Non-adherence was assessed by self-reported questionnaire for all patients attending a single centre outpatient unit. To select only very recent treatments, analysis was restricted to patients who completed a self-reported questionnaire in the last semester. Types of non-adherence investigated: <95% of therapy taken in the last month; <100% doses taken over the last week; timing deviation; drug holidays over the last month; interruption in drug refill over last 3 months. The relationship between different type of non-adherence and virological response was assessed both in univariate and multivariate models.

Relationship between different types of non-adherence behaviour and virological response in unselected HIV-positive cohort