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Background Long-term efficacy of antiretrovirals (ARV) may be blunted by cumulative toxicity. Tenofovir (TDF) is the most widely prescribed antiretroviral agent, and the preferred choice for most drug-naive subjects. Although it shows a safe metabolic profile, much attention has been focused on kidney disturbances and bone demineralization. Since glomerular function is infrequently affected in patients treated with TDF, herein we report the results of extensive exam of the kidney tubular function.

Kidney tubular abnormalities in HIV patients treated with tenofovir with normal glomerular function – results of a prospective study on 284 patients