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Background   Vibrio cholerae  is a human intestinal pathogen and  V. cholerae  of the O139 serogroups are responsible for the current epidemic cholera in China. In this work, we reported the whole genome sequencing of a  V. cholerae  O139 strain E306 isolated from a cholera patient in the 306th Hospital of PLA, Beijing, China.    Results  We obtained the draft genome of  V. cholerae  O139 strain E306 with a length of 4,161,908 bps and mean G + C content of 47.7%. Phylogenetic analysis indicated that strain E306 was very close to another O139 strain,  V. cholerae  MO10, which was isolated during the cholera outbreak in India and Bangladesh. However, unlike MO10, strain E306 harbors the El Tor-specific RS1 element with no pre-CTX prophage (VSK), very similar to those found in some  V. cholerae  O1 strains. In addition, strain E306 contains a SXT/R391 family integrative conjugative element (ICE) similar to ICE Vch Ind4 and SXT  MO10 , and it carries more antibiotic resistance genes than other closest neighbors.    Conclusions  The genome sequence of the  V. cholerae  O139 strain E306 and its comparative analysis with other  V. cholerae  strains we present here will provide important information for a better understanding of the pathogenicity of  V. cholerae  and their molecular mechanisms to adapt different environments.

Genome sequence and comparative analysis of a Vibrio cholerae O139 strain E306 isolated from a cholera case in China