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Primary rectal lymphoma is a rare disease. In this paper we present an unusual case of primary rectal lymphoma which was managed with chemotherapy and discussed by a thorough review of the related literature.    Cases presentation  An 85-years-male patient was diagnosed in Sidi Mohammed Ben Abdellah Hospital as having diffuse large B-cell lymphoma of the rectum at a bulky stage two. This patient was managed successfully with 8 treatment cycles of Cyclophosphamide 750 mg/m2 at day 1 of each cycle, Doxorubicin (50 mg/m2 in the first 4 cycles and 25 mg/m2 in the subsequent cycles) at day 1 of each cycle, Vincristine 1.4 mg/m 2  at day 1 of each cycle, and prednisone 50 mg/m 2  at day 1 to 5 of each cycle.    Conclusion  The optimal treatment of primary rectal lymphoma needs more research studying to be achieved.

Role of chemotherapy in the management of primary rectal lymphoma: a case report and review of the literature