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Background  The Three-amino acid-loop-extension ( TALE ) superfamily of homeodomain-containing transcription factors have been implicated in normal hematopoiesis and in leukemogenesis and are important survival, differentiation, and apoptosis pathway modulators. In this work, we determined the expression levels of  TALE  genes in leukemic-derived cell lines, in blood samples of patients with Acute lymphoblastic leukemia (ALL), and in the blood samples of healthy donors.    Results  Here we show increased expression of  MEIS1, MEIS2,  and  PREP1  genes in leukemia-derived cell lines compared with blood normal cells. High levels of  MEIS1  and  PREP1 , and low levels of  PBX4  expression were also founded in samples of patients with ALL. Importantly, silencing of  MEIS1  decreases the proliferation of leukemia-derived cells but increases their survival after etoposide treatment. Etoposide-induced apoptosis induces down-regulation of MEIS1 expression or  PREP1  up-regulation in chemotherapy-resistant cells.    Conclusions  Our results indicate that up-regulation of  MEIS1  is important for sustaining proliferation of leukemic cells and that down-regulation of  MEIS1  or up-regulation of  PREP1  and  PBX  genes could be implicated in the modulation of the cellular response to chemotherapeutic-induced apoptosis.

journal of experimental and clinical cancer research

MEIS1, PREP1, and PBX4 Are Differentially Expressed in Acute Lymphoblastic Leukemia: Association of MEIS1 Expression with Higher Proliferation and Chemotherapy Resistance