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Purpose  Constitutively decreased  TGFBR1  allelic expression is emerging as a potent modifier of colorectal cancer risk in mice and humans. This phenotype was first observed in mice, then in lymphoblastoid cell lines from patients with microsatellite stable colorectal tumors.    Patients and Methods  We assessed the frequency of constitutively decreased  TGFBR1  allelic expression and association with SNPs covering the  TGFBR1  locus using RNA and DNA extracted from the peripheral blood lymphocytes of 118 consecutive patients with biopsy-proven adenocarcinoma of the colon or the rectum.    Results  We found that 11(9.3%) of 118 patients exhibited decreased  TGFBR1  allelic expression ( TGFBR1  ASE).  TGFBR1  ASE was strongly associated with three SNPs in linkage disequilibrium with each other: rs7034462 (p = 7.2 × 10 -4 ),  TGFBR1* 6A (p = 1.6 × 10 -4 ) and rs11568785 (p = 1.4 × 10 -4 ).    Conclusion  These results confirm the high prevalence of constitutively decreased  TGFBR1  allelic expression among patients with colorectal cancer. The association of this phenotype with  TGFBR1 *6A, rs7034462 and rs1156875 suggests an association between  TGFBR1  SNPs and colorectal cancer, which warrants additional studies.

Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs