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Background   Astrocyte elevated gene-1  ( AEG - 1 ) was originally characterized as a HIV-1-inducible gene in primary human fetal astrocyte. Recent studies highlight a potential role of  AEG-1  in promoting tumor progression and metastasis. The aim of this study was to investigate if  AEG-1  serves as a potential therapeutic target of human neuroblastoma.    Methods  We employed RNA interference to reduce  AEG-1  expression in human neuroblastoma cell lines and analyzed their phenotypic changes.    Results  We found that the knockdown of  AEG-1  expression in human neuroblastoma cells significantly inhibited cell proliferation and apoptosis. The specific downregulation induced cell arrest in the G 0 /G 1  phase of cell cycle. In the present study, we also observed a significant enhancement of chemo-sensitivity to cisplatin and doxorubicin by knockdown of  AEG-1 .    Conclusion  Our study suggests that overexpressed  AEG-1  enhance the tumorogenic properties of neuroblastoma cells. The inhibition of  AEG-1  expression could be a new adjuvant therapy for neuroblastoma.

Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells