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Background  In a human T-cell acute lymphoblastic leukemia (T-ALL) cell line (Molt-4), siRNA-mediated suppression of  BCL11B  expression was shown to inhibit proliferation and induce apoptosis, functions which may be related to genes involved in apoptosis (such as  TNFSF10  and  BCL2L1 ) and TGF-β pathways (such as  SPP1 and  CREBBP ).    Methods  The expression levels of the above mentioned genes and their correlation with the  BCL11B  gene were analyzed in patients with T-ALL using the TaqMan and SYBR Green I real-time polymerase chain reaction technique.    Results  Expression levels of  BCL11B, BCL2L1 , and  CREBBP  mRNA in T-ALL patients were significantly higher than those from healthy controls ( P < 0.05). In T-ALL patients, the  BCL11B  expression level was negatively correlated with the  BCL2L1  expression level ( r  s  = -0.700;  P   < 0.05), and positively correlated with the  SPP1  expression level ( r  s  = 0.683;  P   < 0.05). In healthy controls, the  BCL11B  expression level did not correlate with the  TNFSF10 ,  BCL2L1 ,  SPP1 , or  CREBBP  expression levels.    Conclusions  Over-expression of  BCL11B  might play a role in anti-apoptosis in T-ALL cells through up-regulation of its downstream genes  BCL2L1  and  CREBBP .

Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia