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Background  The neurocircuits that process somatic sensory information in the dorsal horn of the spinal cord are still poorly understood, with one reason being the lack of Cre lines for genetically marking or manipulating selective subpopulations of dorsal horn neurons. Here we describe  Tac2-Cre  mice that were generated to express the  Cre  recombinase gene from the  Tac2  locus.  Tachykinin 2  ( Tac2 ) encodes a neurotransmitter, neurokinin B (NKB).    Results  By crossing  Tac2-Cre  mice with  ROSA26-tdTomato  reporter mice, we directly visualized  Tac2  lineage neurons in the dorsal root ganglia, the dorsal horn of the spinal cord, and many parts of the brain including the olfactory bulb, cerebral cortex, amygdala, hippocampus, habenula, hypothalamus, and cerebellum. This  Tac2-Cre  allele itself was a null allele for the  Tac2  gene. Behavioral analyses showed that  Tac2  homozygous null mice responded normally to a series of algogenic (pain-inducing) and pruritic (itch-inducing) stimuli.    Conclusions   Tac2-Cre  mice are a useful tool to mark specific subsets of neurons in the sensory ganglia, the dorsal spinal cord, and the brain. These mice can also be used for future genetic manipulations to study the functions of  Tac2 -expressing neurons or the functions of genes expressed in these neurons.

Genetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system