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Calcium signalling plays a crucial role in the control of neuronal function and plasticity. Changes in neuronal Ca 2+  concentration are detected by Ca 2+ -binding proteins that can interact with and regulate target proteins to modify their function. Members of the neuronal calcium sensor (NCS) protein family have multiple non-redundant roles in the nervous system. Here we review recent advances in the understanding of the physiological roles of the NCS proteins and the molecular basis for their specificity.

Understanding the physiological roles of the neuronal calcium sensor proteins