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Background  Anaplasmosis, caused by  Anaplasma phagocytophilum  and  Anaplasma platys,  and ehrlichiosis, caused by  Ehrlichia chaffeensis, Ehrlichia ewingii,  the "Panola Mountain  Ehrlichia " and  Ehrlichia muris- like pathogens have been identified as emerging tick borne infectious diseases in dogs and human patients. Persistent intravascular infection with these bacteria is well documented in dogs, but is less well documented in human beings.    Methods  Serology and PCR targeting multiple microbial genes, followed by DNA sequencing, was used to test sequential blood samples. Tissue culture isolation was attempted in two laboratories.    Results   A. platys, E. chaffeensis,  and  E. ewingii  DNA was amplified from two  Anaplasma  and  Ehrlichia  seronegative family members and their dog, all lacking typical symptoms of anaplasmosis or ehrlichiosis. Following treatment with doxycycline, the dog and mother were  Anaplasma  and  Ehrlichia  spp. PCR negative.    Conclusions  Sequential PCR testing provided molecular evidence supporting intravascular persistence of  A. platys  and  Ehrlichia  spp. in two humans and their dog. Diagnosticians and clinicians should consider the potential for co-infections due to these tick borne organisms.

Intravascular persistence of Anaplasma platys, Ehrlichia chaffeensis, and Ehrlichia ewingii DNA in the blood of a dog and two family members