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Background   Psoroptes cuniculi  can parasitise the ear canal of the rabbit, and cause the afflicted animals to cease feeding and become severely debilitated, sometimes resulting in death. In this study, we examined the oxidative status and inflammatory level of the peripheral blood of rabbits infested with  Psoroptes cuniculi  and investigated the pathogenesis of this disease.    Methods  A total of 24 rabbits were divided into a healthy rabbit group and two infested rabbit groups. After weighing the rabbits, approximately 5 ml of blood was obtained from each animal. Then, the blood serum was extracted and used to assess the levels of antioxidant enzymes and inflammatory factors.    Results  Compared to the healthy rabbits, the activities of catalase and glutathione-S-transferase and the level of malonyldialdehyde were increased, but the activity of superoxide dismutase was reduced in the infested rabbits. At the same time, a variety of inflammatory cells were activated, and the levels of inflammatory factors such as prostaglandin E 2 , interleukin-6, interleukin-8 and transforming growth factor-β1 were increased in peripheral blood.    Conclusion  Animal acariasis was associated with immunosuppressive disorders and inflammatory reaction. These results advance our understanding of the pathogenesis of  Psoroptes cuniculi  infestation in rabbits and can help guide the effectual treatment of this disease in clinics.

The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi