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Background   Leishmania tropica  is a causative agent of cutaneous leishmanaisis in the Middle East, North Africa and parts of southeastern Europe. Although transmission of  L. tropica  has been reported as anthroponotic, in Israel it was found to have a zoonotic pattern.    Findings  A one year old male Pekingese dog from Maale Adumim, a focus of  L. tropica  human cutaneous leishmaniasis near Jerusalem, was presented by its owner with a large proliferative red mucocutaneous lesion on the lip between the mouth and nose. Physical examination and a biochemistry panel were normal and a complete blood count showed mild leukocytosis with lymphocytosis and eosinophilia. A biopsy of the lesion was suggestive of the presence of  Leishmania  organisms. Serology for  Leishmania  sp. by ELISA was positive and an aspirate from the lesion showed a large number of  Leishmania  amastigotes. ITS1-HRM-PCR of the lesion was positive and sequencing indicated that infection was caused by  L. tropica,  which was also cultured from the lesion .  Blood PCR was negative. The dog responded well to allopurinol treatment and its lesion shrunk considerably within one month of therapy and healed after two months.    Conclusions  Only a few cases of dog infection with  L. tropica  have been described to date. They were reported from Morocco and Iran and involved infection of visceral organs. This is the first report of focal mucocutaneous  L. tropica  infection in a dog and its response to anti-leishmanial treatment. Domestic and wild canines should be evaluated for being possible animal reservoirs for human  L. tropica  infection in endemic areas or merely accidental hosts.

Mucocutaneous Leishmania tropica infection in a dog from a human cutaneous leishmaniasis focus