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Background  Malaria remains a public health problem in the remote and poor area of Yunnan Province, China. Yunnan faces an increasing risk of imported malaria infections from Mekong river neighboring countries. This study aimed to identify the high risk area of malaria transmission in Yunnan Province, and to estimate the effects of climatic variability on the transmission of  Plasmodium vivax  and  Plasmodium falciparum  in the identified area .Methods  We identified spatial clusters of malaria cases using spatial cluster analysis at a county level in Yunnan Province, 2005–2010, and estimated the weekly effects of climatic factors on  P. vivax  and  P. falciparum  based on a dataset of daily malaria cases and climatic variables. A distributed lag nonlinear model was used to estimate the impact of temperature, relative humidity and rainfall up to 10–week lags on both types of malaria parasite after adjusting for seasonal and long-term effects.    Results  The primary cluster area was identified along the China–Myanmar border in western Yunnan. A 1°C increase in minimum temperature was associated with a lag 4 to 9 weeks relative risk (RR), with the highest effect at lag 7 weeks for  P. vivax  (RR = 1.03; 95% CI, 1.01, 1.05) and 6 weeks for  P. falciparum  (RR = 1.07; 95% CI, 1.04, 1.11); a 10-mm increment in rainfall was associated with RRs of lags 2-4 weeks and 9-10 weeks, with the highest effect at 3 weeks for both  P. vivax  (RR = 1.03; 95% CI, 1.01, 1.04) and  P. falciparum  (RR = 1.04; 95% CI, 1.01, 1.06); and the RRs with a 10% rise in relative humidity were significant from lag 3 to 8 weeks with the highest RR of 1.24 (95% CI, 1.10, 1.41) for  P. vivax  at 5-week lag.    Conclusions  Our findings suggest that the China–Myanmar border is a high risk area for malaria transmission. Climatic factors appeared to be among major determinants of malaria transmission in this area. The estimated lag effects for the association between temperature and malaria are consistent with the life cycles of both mosquito vector and malaria parasite. These findings will be useful for malaria surveillance–response systems in the Mekong river region.

Impact of climate variability on Plasmodium vivax and Plasmodium falciparum malaria in Yunnan Province, China