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Background  Sand fly saliva has been postulated as a potential vaccine or as a vaccine component within multi component vaccine against leishmaniasis. It is important to note that these studies were performed using long-term colonized  Phlebotomus papatasi . The effect of sand flies colonization on the outcome of  Leishmania  infection is reported.    Results  While pre-immunization of mice with salivary gland homogenate (SGH) of long-term colonized (F5 and beyond) female  Phlebotomus papatasi  induced protection against  Leishmania major  co-inoculated with the same type of SGH, pre-immunization of mice with SGH of recently colonized (F2 and F3) female  P. papatasi  did not confer protection against  L. major  co-inoculated with the same type of SGH. Our data showed for the first time that a shift from lack of protection to protection occurs at the fourth generation (F4) during the colonization process of  P. papatasi .    Conclusion  For the development of a sand fly saliva-based vaccine, inferences based on long-term colonized populations of sand flies should be treated with caution as colonization of  P. papatasi  appears to modulate the outcome of  L. major  infection from lack of protection to protection.

parasites and vectors

Colonization of Phlebotomus papatasi changes the effect of pre-immunization with saliva from lack of protection towards protection against experimental challenge with Leishmania major and saliva