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Background  The phenotypic antimicrobial susceptibility testing (AST) of bacteria depends on minimal inhibitory concentration breakpoints issued by national and international breakpoint committees. The current study was performed in order to test the influence of different AST standards on local cumulative AST data and on antibiotic consumption.    Methods  Automated AST was performed with clinical isolates of  Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus,  coagulase-negative staphylococci,  Enterococcus faecalis , and  E. faecium . From each species 100 prospectively collected non-duplicate clinical isolates were tested and MIC data were interpreted according to the interpretation standards issued by DIN and EUCAST, respectively. In addition cumulative AST data from clinical isolates and antibiotic consumption were monitored before and after implementation of new EUCAST MIC breakpoints.    Results  The susceptibility rate of  P. aeruginosa  against piperacillin and gentamicin, and of  C. freundii  against piperacillin/tazobactam increased significantly, whereas the susceptibility rates of  E. cloacae ,  S. marcescens , and  M. morganii  against ciprofloxacin decreased significantly after switching from DIN to EUCAST MIC breakpoints. These changes in the cumulative antibiotic resistance pattern were reflected by enhanced consumption of piperacillin/tazobactam after implementation of EUCAST MIC breakpoints.    Conclusions  These data show that changes of AST breakpoints have a significant influence on local cumulative AST data and on antibiotic consumption.

Impact of minimal inhibitory concentration breakpoints on local cumulative bacterial susceptibility data and antibiotic consumption