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Background   Crassocephalum bauchiense  is a flowering plant, found in the West Region of Cameroon. Previous studied has highlighted the antibacterial and the dermal toxicological safety as well as the immunomodulatory activities of the ethyl acetate extract of its dry leaves. As an extension of the previous researches, the current work has been undertaken to evaluate the  in vitro  antifungal and antioxidant activities of  C. bauchiense  dried leaves ethyl acetate extract and fractions.    Methods  The extract was obtained by maceration in ethyl acetate and further fractionated into six fractions labeled F 1  to F 6  by flash chromatography. The antifungal activity of the extract and fractions against yeasts and dermatophytes was evaluated using broth microdilution method. Antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO) and β-carotene - linoleic acid assays.    Results  The extract (MIC = 0.125 - 4 mg/ml) was found to be more active on dermatophytes and yeasts compared to the fractions. The ethyl acetate extract and fractions exhibited strong scavenging activity on DPPH (CI 50  = 28.57 - 389.38 μg/ml). The fractions F 3  and F 6  expressed best antioxidant activity on DPPH radicals compared to the crude extract.    Conclusion  The results of these findings clearly showed that  C. bauchiense  ethyl acetate extract has a significant antifungal and antioxidant activity. It is therefore a source of active compounds that might be used as antifungal and antioxidant agents.

Antifungal and antioxidant activity of Crassocephalum bauchiense (Hutch.) Milne-Redh ethyl acetate extract and fractions (Asteraceae)