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Background  The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy.    Results  The extract of  Cinnamomum zeylanicum  against  Escherichia coli  ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of  Dorstenia psilurus  was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine -β-  Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with Erythromycin (ERY).    Conclusion  The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.

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Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes