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Background  Previous studies have revealed altered expression of epidermal growth factor receptor (EGFR)-family members and their endogenous inhibitor leucine-rich and immunoglobulin-like domains 1 (LRIG1) in renal cell carcinoma (RCC). In this study, we analyzed the gene expression levels of EGFR-family members and LRIG1, and their possible associations with clinical parameters in various types of RCC.    Methods  Gene expression levels of EGFR–family members and LRIG1 were analyzed in 104 RCC samples, including 81 clear cell RCC (ccRCC), 15 papillary RCC (pRCC), and 7 chromophobe RCC (chRCC) by quantitative real-time RT-PCR. Associations between gene expression levels and clinical data, including tumor grade, stage, and patient survival were statistically assessed.    Results  Compared to kidney cortex,  EGFR  was up-regulated in ccRCC and pRCC,  LRIG1  and  ERBB2  were down-regulated in ccRCC, and  ERBB4  was strongly down-regulated in all RCC types.  ERBB3  expression did not differ between RCC types or between RCC and the kidney cortex. The expression of the analyzed genes did not correlate with patient outcome.    Conclusions  This study revealed that the previously described up-regulation of  EGFR  and down-regulation of  ERBB4  occurred in all analyzed RCC types, whereas down-regulation of  ERBB2  and  LRIG1  was only present in ccRCC. These observations illustrate the need to evaluate the different RCC types individually when analyzing molecules of interest and potential biological markers.

Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma