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Background  Calcium signals ([Ca 2+ ] i ) direct many aspects of embryo development but their regulation is not well characterised. Ryanodine receptors (RyRs) are a family of intracellular Ca 2+  release channels that control the flux of Ca 2+  from internal stores into the cytosol. RyRs are primarily known for their role in excitation-contraction coupling in adult striated muscle and  ryr  gene mutations are implicated in several human diseases. Current evidence suggests that RyRs do not have a major role to play prior to organogenesis but regulate tissue differentiation.    Findings  The sequences of the five zebrafish  ryr  genes were confirmed, their evolutionary relationship established and the primary sequences compared to other vertebrates, including humans. RyRs are differentially expressed in slow ( ryr1a ), fast ( ryr3 ) and both types ( ryr1b ) of developing skeletal muscle. There are two  ryr2  genes ( ryr2a  and  ryr2b ) which are expressed exclusively in developing CNS and cardiac tissue, respectively. In addition,  ryr3  and  ryr2a  mRNA is detectable in the initial stages of development, prior to embryonic axis formation.    Conclusions  Our work reveals that zebrafish  ryr  genes are differentially expressed throughout the developing embryo from cleavage onwards. The data suggests that RyR-regulated Ca 2+  signals are associated with several aspects of embryonic development, from organogenesis through to the differentiation of the musculoskeletal, cardiovascular and nervous system. These studies will facilitate further work to explore the developmental function of RyRs in each of these tissue types.

Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development