English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background  Malaria remains a major public health problem, especially in tropical and subtropical regions because of the emergence and widespread of antimalarial drug resistance. Traditional medicine represents one potential source of new treatments. Here, we investigated the  in vitro  antiplasmodial activity of bark extracts from two  Fabaceae  species  (Tetrapleura tertaptera and Copaifera religiosa ) traditionally used to treat malaria symptoms in Haut-Ogooué province, Gabon.    Findings  The antiplasmodial activity of dichloromethane and methanolic extracts was tested on  P. falciparum  strains FCB (chloroquine-resistant) and 3D7 (chloroquine-sensitive) and on fresh clinical isolates, using the DELI method. Host cell toxicity was analyzed on MRC-5 human diploid embryonic lung cells using the MTT test.  The dichloromethane extracts of the two plants had interesting activity (IC 50  between 8.5 ± 4.7 and 13.4 ± 3.6 μg/ml). The methanolic extract of  Tetrapleura tetraptera  was less active (IC 50  around 30 μg/ml) and the methanolic extract of  Copaifera religiosa  was inactive. The selectivity index (toxicity/antiplasmodial activity) of the dichloromethane extract of  Tetrapleura tetraptera  was high (around 7), while the dichloromethane extract of  Copaifera religiosa  had the lowest selectivity (0.6). The mean IC 50  values for field isolates were less than 1.5 μg/ml for dichloromethane extracts of both plants, while methanolic extracts of  Tetrapleura tetraptera  showed interesting activity (IC 50  = 13.1 μg/ml). The methanolic extract of  Copaifera religiosa  was also inactive on field isolates.    Conclusions  Dichloromethane extracts of  Tetrapleura tetraptera  and  Copaifera religiosa , two plants used to treat malaria in Gabon, had interesting antiplasmodial activity  in vitro . These data provide a scientific rationale for the traditional use of these plants against malaria symptoms. Bioactivity-guided phytochemical analyses are underway to identify the active compounds.

In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa