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Background  Heat shock proteins (HSPs) are important candidates for the development of vaccines because they are usually able to promote both humoral and cellular immune responses in mammals. We identified and characterized the  hsp60-hsp10  bicistronic operon of the animal pathogen  Corynebacterium pseudotuberculosis , a Gram-positive bacterium of the class  Actinobacteria , which causes caseous lymphadenitis (CLA) in small ruminants.    Findings  To construct the DNA vaccine, the  hsp60  gene of  C. pseudotuberculosis  was cloned in a mammalian expression vector. BALB/c mice were immunized by intramuscular injection with the recombinant plasmid (pVAX1/ hsp60 ).    Conclusion  This vaccination induced significant anti-hsp60 IgG, IgG1 and IgG2a isotype production. However, immunization with this DNA vaccine did not confer protective immunity.

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Molecular characterization of the Corynebacterium pseudotuberculosis hsp60-hsp10 operon, and evaluation of the immune response and protective efficacy induced by hsp60 DNA vaccination in mice