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Background  Nephrogenic systemic fibrosis (NSF) is a fibrosing disorder that exhibits CD34 expression in the majority of lesional spindle cells. Several features of NSF bear similarity to Kaposi sarcoma.    Findings  Skin lesions procured from two male NSF patients were found to be negative for HHV8 (LNA-1) by means of immunohistochemsitry.    Conclusion  This finding negates a role for HHV8 in the pathogenesis of NSF.

Absence of human herpes virus-8 (HHV8) in nephrogenic systemic fibrosis