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Background Tacrolimus (Tac) is the mainstay of standard immunosuppressive regime in renal transplantation today. However, it needs regular drug level monitoring in view of narrow therapeutic window to keep blood level in therapeutic range. The objective of the study was to assess the potential influence of a functional polymorphism in CYP3A5*3 gene on dose requirements and trough blood levels of tacrolimus in renal transplant patients

Influence of CYP3A5 polymorphism on tacrolimus drug dosing in Indian renal allograft recipients: initial experience