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Background Congenital adrenal hyperplasia (CAH) or 46, XX DSD is a result of a defect in the P450 adrenal enzymes responsible for the conversion of progesterones to glucocorticoids and mineralocorticoids. This syndrome affects both males and females but causes ambiguous genitalia only in females. Mutations in the CYP21 cause 90% of cases of CAH. The remainder of CAH cases is distributed among deficiencies of P450c11, CYP17 or steroid acute regulatory protein, depending on the ethnic origin of patients. Rarely, 46, XX, DSD can result from exposure to exogenous androgens such as those given in the past to prevent loss of pregnancy. The present study was conducted to replicate a family based correlation of C to T transition polymorphism in Congenital adrenal hyperplasia (CAH).

A family based study on T-C transition polymorphism in Cyp17a1 gene in Indian children