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Background Plasmodium falciparum malaria is the most severe form of malaria causing morbidity and mortality worldwide. The key event in P. falciparum pathogenesis is the sequestration of the infected erythrocytes to the capillary endothelium, mediated by the receptor, Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). PfEMP1 has distinct characteristics of binding to varied host ligands including Inter Cellular Adhesion Molecule (ICAM-1). Polymorphisms in the gene encoding ICAM1 influence the rate of progression or confer protection from or susceptibility to malaria parasite infection. The objective of our study was to evaluate the frequency of ICAM-1 SNP in exon 6 (rs5498, K469E) in the Indian population and compare it with the global population influenced by the parasitic infection.

Genetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1): candidate gene in susceptibility to malaria in the Indian population